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Graphical Abstract Highlights d Reconstruction of a genome-scale metabolic model for HCC tumors d Revealing metabolic alterations in HCC d Analysis of the heterogeneous expression of ACSS1 and ACSS2 between HCC tumors d Induction of ACSS1 in murine and human HCC samples under hypoxic conditions SUMMARY Hepatocellular carcinoma (HCC) is a deadly form of liver cancer that is increasingly prevalent. We analyzed global gene expression profiling of 361 HCC tumors and 49 adjacent noncancerous liverdoi:10.1016/j.celrep.2015.10.045 pmid:26655911 fatcat:knq7xujs4fc3hojecjltf5zy7e