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Aryl bromide/triflate selectivities reveal mechanistic divergence in palladium-catalysed couplings; the Suzuki–Miyaura anomaly
Synthetic aspects; numbering follows the main manuscript. Synthesis of triflate (7) 1 A Schlenk tube was charged with 2-bromo-4,5-difluorophenol (1.64 ml, 3g, 1.44·10 -2 mol) under nitrogen and 9 ml of pyridine. The stirred solution is cooled to 0º C and then trifluoromethanesulfonic anhydride, 2.67 ml, is added very slowly through the rubber stopper via a syringe. The temperature is maintained at 0º C for 5 min and then allowed to warm to room temperature and stirred overnight (20-25 h). Thedoi:10.1039/b701517h pmid:17457427 fatcat:7anvequxwzbefmg6zftqscsaky