This study aimed to analyse levels of heavy metals (Pb, Hg Background: and Cd) in the aquatic body, gills and stomach of the oysters Crassostrea and , the metallothionein (MT) level in the cuculata Crassostrea glomerata gills and stomach of both oysters, and relationships between heavy metals level (Pb, Hg and Cd) in the gills and stomach to MT level in both species of oysters. The research method utilized was a descriptive method. The Methods: oyster samples were taken from three stations:

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... ang Biru, Popoh and Prigi beaches. MT values were assessed using confocal laser scanning microscopy. The heavy metal levels were assessed using atomic absorption spectrophotometry method. Both oyster heavy metal content obtained in the southern coastal Results: waters exceeded the safe limit set by the State Minister of Environment No. 51 of 2004. In general, the expression of MT was found to be higher in stomach tissue compared to gill tissue. The levels of the heavy metals Pb, Hg, and has a strong Conclusions: relationship with MT levels in the gills and stomach in both types of oysters.