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Tissue Transglutaminase and the Progression of Human Renal Scarring
2003
Journal of the American Society of Nephrology
Experimental renal scarring indicates that tissue transglutaminase (tTg) may be associated with the accumulation of extracellular matrix (ECM), both indirectly via TGF-1 activation and directly by the formation of ⑀(␥-glutamyl) lysine dipeptide bonds within the ECM. The latter potentially accelerates deposition and confers the ECM with resistance to proteolytic digestion. Studied were 136 human renal biopsy samples from a range of chronic renal diseases (CRD) to determine changes in tTg and
doi:10.1097/01.asn.0000079614.63463.dd
pmid:12874459
fatcat:hfrd3zm6djbvzo5n5vkeanwuja