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Subcellular localization of Pseudomonas pyocyanin cytotoxicity in human lung epithelial cells
2003
American Journal of Physiology - Lung cellular and Molecular Physiology
The Pseudomonas aeruginosa secretory product pyocyanin damages lung epithelium, likely due to redox cycling of pyocyanin and resultant superoxide and H2O2 generation. Subcellular site(s) of pyocyanin redox cycling and toxicity have not been well studied. Therefore, pyocyanin's effects on subcellular parameters in the A549 human type II alveolar epithelial cell line were examined. Confocal and electron microscopy studies suggested mitochondrial redox cycling of pyocyanin and extracellular H 2O2
doi:10.1152/ajplung.00316.2002
pmid:12414438
fatcat:ajjgem3bibamjpm57qmfx5nt5y