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Conformational changes in Sindbis virions resulting from exposure to low pH and interactions with cells suggest that cell penetration may occur at the cell surface in the absence of membrane fusion
2004
Virology
Alphaviruses have the ability to induce cell -cell fusion after exposure to acid pH. This observation has served as an article of proof that these membrane-containing viruses infect cells by fusion of the virus membrane with a host cell membrane upon exposure to acid pH after incorporation into a cell endosome. We have investigated the requirements for the induction of virus-mediated, low pH-induced cell -cell fusion and cell -virus fusion. We have correlated the pH requirements for this
doi:10.1016/j.virol.2004.03.046
pmid:15207623
fatcat:7rfgaqi6bfbh3lkjrdnxctx5hq