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Optical coherence tomography ͑OCT͒ has already proven an important clinical tool for imaging and diagnosing retinal diseases. Concerning the standard commercial ophthalmic OCT systems, speckle noise is a limiting factor with respect to resolving relevant retinal features. We demonstrate successful suppression of speckle noise from mutually aligning a series of in vivo OCT recordings obtained from the same retinal target using the Stratus system from Humphrey-Zeiss. Our registration technique isdoi:10.1117/1.2772879 pmid:17867797 fatcat:vgeya6yzojflpk7wroif2ig3wq