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Drug-induced liver injury in a COVID-19 patient: potential interaction of remdesivir with P-glycoprotein inhibitors

Emiel Leegwater, Anne Strik, Erik B Wilms, Liesbeth B E Bosma, David M Burger, Thomas H Ottens, Cees van Nieuwkoop
2020 Clinical Infectious Diseases  

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https://web.archive.org/web/20220808154049/https://watermark.silverchair.com/ciaa883.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAy4wggMqBgkqhkiG9w0BBwagggMbMIIDFwIBADCCAxAGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMjvivf0F3-kfu8STiAgEQgIIC4UbnP2QgGMyFKwmo5y1-6uHI8nQuad3MITpSyN0026y07Jti5nrdf_ye3buf5GlwlNRmhlDT-cgbs5fBgOgQFb44wFPNQMmhnkjinj8ZdvjmJN-oqo1DCIeHiCkThUhUzK4OZMHvC2LIusuVCc4JP68RXPfiOCrDxlvAyoJmQRWpxvy-DeknEL2zNowLCnpcymYuzxyxU5KdmKFxnuSqRk1hS9fFNoNQvJ6OU0FgbaQsmvo_l-jdAg1BerHFkN4FhZ7HZa2oSqq078uPjJziKbpASWNVmRfv92j3VoagQrwLvrEO9VpQ7RpANZUx7OtRl0thxTcRtBQOfJ_0_7Rej85ydR4iLkUZGgILfADH6DLiSt_brqVBYzXDPbt94ufTe3MGQHC2jJvxvqZFMI2swYy_7xHmO9K5i__lH0Hfze-UJdP4i9LKb_3MxGF2dUcbheoSCpMB37rQaSu7yeor9ZjLOu2eqhqQRulpEqoNaJzWZX2fjqh2dtZ5URqiFNyoeR7IWvhfo8ya128x9ZFUqTlDbaUriPmLU98SjcT9olx8uG-viBEbFiRo9OqBPWGoIvhuYK-4E57uAGt8IYoPX6qjb7eByj_NSnF5YXFVAsIVQ-g5a7OgHKwNmoXhA-b-3pT1knejVhLVvZV8fv2JEZXbSwYESlJ2YnNxkg1K4POaGuYb_IwDvMZ5DGNC-z1ccAG8cSiowoFeY0VSai-r-RGk2uKdblREo5Abhe1jlXKvLz0xDUB8xPpU7sG7gAAeXWwSyrTul8GurTx8L94jJM9iWduMlhyqQvYka7v4a-cLAoRjD1ahQXplFo8_oltXRxnI53o4kxGN1CXdeVqczWKkOoHbh7Vb2LPwX5wM3e0EOwfh5xvw3LEN5VZ0tIwgo3IkzpeNd9HK37bSdKkFC9NL7fUhEa0kIjG-kG48o7cBrIvSoYdPP5xxCswZErFfVFziyghAJptBIhYNf2qOBA7v

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We report a case of a male with COVID-19 who developed acute hepatotoxicity related to remdesivir with probable interaction of P-glycoprotein (P-gp) inhibitors. Until further details upon this interaction become available, we recommend physicians to be cautious with the prescription of P-gp inhibitors in patients receiving remdesivir therapy.
doi:10.1093/cid/ciaa883 pmid:32594120 fatcat:gvetydsvhbehpdpsginfq3exya
Citation

Emiel Leegwater, Anne Strik, Erik B Wilms, Liesbeth B E Bosma, David M Burger, Thomas H Ottens, Cees van Nieuwkoop. "Drug-induced liver injury in a COVID-19 patient: potential interaction of remdesivir with P-glycoprotein inhibitors." Clinical Infectious Diseases (2020)