Deep learning-based image quality improvement of 18F-fluorodeoxyglucose positron emission tomography: a retrospective observational study

Junichi Tsuchiya, Kota Yokoyama, Ken Yamagiwa, Ryosuke Watanabe, Koichiro Kimura, Mitsuhiro Kishino, Chung Chan, Evren Asma, Ukihide Tateishi
2021 EJNMMI Physics  
Background Deep learning (DL)-based image quality improvement is a novel technique based on convolutional neural networks. The aim of this study was to compare the clinical value of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) images obtained with the DL method with those obtained using a Gaussian filter. Methods Fifty patients with a mean age of 64.4 (range, 19–88) years who underwent 18F-FDG PET/CT between April 2019 and May 2019 were included in the study. PET images
more » ... obtained with the DL method in addition to conventional images reconstructed with three-dimensional time of flight-ordered subset expectation maximization and filtered with a Gaussian filter as a baseline for comparison. The reconstructed images were reviewed by two nuclear medicine physicians and scored from 1 (poor) to 5 (excellent) for tumor delineation, overall image quality, and image noise. For the semi-quantitative analysis, standardized uptake values in tumors and healthy tissues were compared between images obtained using the DL method and those obtained with a Gaussian filter. Results Images acquired using the DL method scored significantly higher for tumor delineation, overall image quality, and image noise compared to baseline (P < 0.001). The Fleiss' kappa value for overall inter-reader agreement was 0.78. The standardized uptake values in tumor obtained by DL were significantly higher than those acquired using a Gaussian filter (P < 0.001). Conclusions Deep learning method improves the quality of PET images.
doi:10.1186/s40658-021-00377-4 pmid:33765233 fatcat:tg4rxkkb6re47gfpcgsybd3e3i