INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND LIFE SCIENCES Formulation and Evaluation of Omeprazole Buccoadhesive Tablets: Effect of Polymers

S Prathyusha, S Prathima, K Arshad, Ahmed Khan, C Sowmya
International Journal of Research in Pharmacy and Life Sciences   unpublished
Omeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H + /K + -ATPase in the gastric parietal cell. By acting specifically on the proton pump. omeprazole blocks the final step in acid production, thus reducing gastric is used as anti ulcer agent and enzyme inhibitor [8] . Freely soluble in ethanol and methanol, and slightly soluble in acetone, isopropyl alcohol, and very slightly soluble in water.The objective of the present
more » ... f the present investigation was the design and in vitro evaluation of more promising Omeprazole buccoadhesive tablets:effect of polymers based on (i) adhesive polymers like carbopol(940), (ii) rate controlling polymers like xanthum gum,sodium alginate, Hpmc, sodium cmc Materials and Methods Materials Omeprazole were kindly provided by Banglore fine chem. Abstract For the development of omeprazole buccoadhesive tablets, we studied the release and bioavailability of omeprazole delivered by buccal adhesive tablets. These tablets composed of carbopol, xanthum gum, sodium cmc, Hpmc, sodium alginate, croscarmellose sodium. Croscarmellose sodium enhanced the release of omeprazole from the tablets. It may be attached to the human cheek without collapse and it enhanced the stability of omeprazole in human saliva for at least 4 h, giving a fast release of omeprazole. Tablets were prepared by direct compression method and evaluated for buccoadhesive strength and in vitro dissolution parameters. Total twelve formulations were developed with varying concentration of polymers. Formulation F3 showed good buccoadhesive strength. Formulations F1 & F7 showed maximum release 98.75% and 99.96% in 7hrs. The selected best formulations followed zero order drug release pattern. FTIR studies showed no evidence of interaction between drug and polymers. The results indicate the suitable buccoadhesive tablet of Omeprazole with desired property can be prepared.