Changes in the metabolism and transport of bile acids lead to pathological conditions. This highlights the importance of a balanced circulation of these substances due to their significant role in homeostasis. The main purpose of the study is to evaluate the indicator "total bile acids" in minks with shed keeping in the climatic conditions of the Tver region. The study of the total amount of bile acids is a promising way to identify pathologies of the hepatobiliary system. Venous blood was

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... from 200 minks for analysis. As a result of a clinical study of mink blood, no significant pathological changes were revealed. The data obtained make it possible to refer the above animals to the category of "clinically healthy" for further exploratory studies.