Engineering the synchronization of neuron action potentials using global time-delayed feedback stimulation

Craig G. Rusin, Sarah E. Johnson, Jaideep Kapur, John L. Hudson
2011 Physical Review E  
We experimentally demonstrate the use of continuous, time-delayed, feedback stimulation for controlling the synchronization of neuron action potentials. Phase based models were experimentally constructed from a single synaptically-isolated cultured hippocampal neuron. These models were used to determine the stimulation parameters necessary to produce the desired synchronization behavior in the action potentials of a pair of neurons coupled through a global time-delayed interaction. Measurements
more » ... ction. Measurements made using a dynamic clamp system confirm the generation of the synchronized states predicted by the experimentally constructed phase model. This model was then utilized to extrapolate the feedback stimulation parameters necessary to disrupt the action potential synchronization of a large population of globally interacting neurons.
doi:10.1103/physreve.84.066202 pmid:22304173 fatcat:mvgbpcg4qvhibghybxf7ungjvm