Pharmacological airway clearance strategies in bronchiectasis [chapter]

P.T. Bye, E.M.T. Lau, M.R. Elkins
2011 Bronchiectasis  
Impaired mucociliary clearance and mucus retention contribute to the chronic cycle of airway inflammation, infection and damage in bronchiectasis. There is a strong rationale for the use of pharmacological strategies to aid airway clearance, often in combination with chest physiotherapy. Despite the availability of many candidate mucoactive agents, the evidence base for recommending these agents is currently limited. Recent research and trials have focused particularly on osmotic agents
more » ... otic agents (hypertonic saline and mannitol), which increase airway hydration, and early studies appear promising for both of these agents. Dornase alfa is not effective in non-cystic fibrosis (CF) bronchiectasis, which underscores the importance of conducting high quality and adequately powered trials that specifically address the therapeutic options for non-CF bronchiectasis.
doi:10.1183/1025448x.10004610 fatcat:43wju3jh45ehhdavxpkzoclprq