Optimization strategies in the modelling of SG-SMB applied to separation of phenylalanine and tryptophan

Leôncio Diógenes Tavares Câmara
2014 Journal of Physics, Conference Series  
To cite this article: Leôncio Diógenes Tavares Câmara 2014 J. Phys.: Conf. Ser. 490 012033 View the article online for updates and enhancements. Related content Modifier mass transfer kinetic effect in the performance of solvent gradient simulated moving bed (SG-SMB) process L D T Câmara -Evaluation of the Use of Complex Mineral Concentrate as a Modifier Steel R A Gizatulin, S N Fedoseev and R S Dariev -Chemical modification of oxide surfaces with organophosphorus(V) acids and their esters
more » ... d their esters Pavel G Mingalyov and Georgii V Lisichkin -This content was downloaded from IP address on 24/07 Abstract. The solvent-gradient simulated moving bed process (SG-SMB) is the new tendency in the performance improvement if compared to the traditional isocratic solvent conditions. In such SG-SMB process the modulation of the solvent strength leads to significant increase in the purities and productivity followed by reduction in the solvent consumption. A stepwise modelling approach was utilized in the representation of the interconnected chromatographic columns of the system combined with a lumped mass transfer model between the solid and liquid phase. The influence of the solvent modifier was considered applying the Abel model which takes into account the effect of modifier volume fraction over the partition coefficient. Correlation models of the mass transfer parameters were obtained through the retention times of the solutes according to the volume fraction of modifier. The modelling and simulations were carried out and compared to the experimental SG-SMB separation unit of the amino acids Phenylalanine and Tryptophan. The simulation results showed the great potential of the proposed modelling approach in the representation of such complex systems. The simulations showed great agreement fitting the experimental data of the amino acids concentrations both at the extract as well as at the raffinate. A new optimization strategy was proposed in the determination of the best operating conditions which uses the phi-plot concept.
doi:10.1088/1742-6596/490/1/012033 fatcat:kkjg7k7bmbcz5k7ov54j2gs6z4