Metabolic Level and Hypothalamic-Pituitary-Gonadal Axis (HPGA) Function in Prepubertal Male Children with Simple Obesity and Sexual Retardation [post]

2019 unpublished
With the increasing morbidity of obesity in children and adolescents in worldwide,more and more diseases are recognized by people. Our aim was to study the effects of obesity on metabolic level and hypothalamic-pituitary-gonadal axis function in prepubertal males.Ninety-two patients participated in our study and then were divided into two groups according to whether the peak value of LH was less than 4.8 mIU/ml in Gonadotropin-releasing hormone(GnRH) stimulation test. All of them were underwent
more » ... a comprehensive physical examination,laboratory tests and imaging examinations.The obesity with sexual retardation group in bone age, BMISDS, blood pressure, testicular volume and penile length, IGF-1SDS, HOMA-IR, AST, ALT, HDL-C, LDL-C and triglyceride were significantly different from control group (P < 0.01).There were significant differences in age, BMISDS, diastolic blood pressure, penile length and HDL-C between normal HPGA group and hypogonadotropic hypogonadism(HH) group (P < 0.01).FSH and INB had statistical differences before and after human chorionic gonadotropin (HCG) stimulation test between the two groups(P < 0.05), while T and DHT had statistical differences after the test (P < 0.01). Conclusion Prepubertal obesity can cause metabolic disorders and increase the risk of metabolic syndrome, and lead to sexual retardation. Background Obesity has become one of the most common chronic diseases among children and adolescents since the 1980s, which seriously affects their growth and development. [1] . According to statistics, the overweight rate of children over the age of 7 has increased from 2.1% to 12.2%, while the obesity rate has increased from 0.5% to 7.3% the corresponding number of overweight and obesity has increased from 6.15 million to 34.96 million in the past 30 years in China [2] . Simple obesity is a state of excessive accumulation of adipose tissue in the whole body caused by many factors, such as excessive energy intake, metabolic disorder and insufficient energy consumption and so on. The incidence of obesity-related diseases in children is also increasing, such as hyperinsulinemia, type 2 diabetes mellitus, obesity sleep apnea syndrome, non-alcoholic fatty liver disease (NAFLD) and so on. Studies have shown that obesity can also lead to abnormal sexual development in male children [4] , with the clinical manifestations of small penis, small testicles, gynecomastia and so on. The purpose
doi:10.21203/rs.2.10639/v1 fatcat:2sugktiyrrag3oncexubsfjqwy