Magnetic Particle Imaging of liver tumors in small animal models

Jan Dieckhoff, Michael G. Kaul, Tobias Mummert, Caroline Jung, Johannes Salamon, Gerhard Adam, Tobias Knopp, Dorothee Schwinge, Harald Ittrich
In vivo liver visualization can be realized with Magnetic Particle Imaging (MPI) since a major part of the iron oxide nanoparticles - intravenously injected and imaged with MPI - is finally taken up by the mononuclear phagocytic system (MPS) of the liver. In this study, the possibility to detect and characterize liver tumors with MPI was analyzed. Mice developing hepatocellular carcinoma (HCC) were continuously screened with high-field magnetic resonance imaging (MRI). In case of liver lesions
more » ... ith diameters larger 5 mm, the mice were sequentially imaged with MRI and MPIaftertheintravenousinjectionofferucarbotran(Resovist(R)).Forcomparisonoflivermorphologiesrepresented by MPI and MRI, image data of both modalities were fused assisted by external MPI and MRI fiducial markers. A good correlation between MPI and MRI images was found with image analysis-based 2-D correlation coefficients of around 0.7. Liver lesions - characterized by a missing accumulation of ferucarbotran - led to signal gaps or drops in the MPI signal depending on their actual size and location. While lesions with diameters larger than 5 mm caused visible effects in the MPI signal, smaller sized lesions did not. This was mainly attributed to the comparable low MPI resolution of a few millimeters in this study.
doi:10.18416/ijmpi.2017.1707003 fatcat:rzgxkpxu5nc4ritqm5dlwlrile