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Nuclear Mitochondrial DNA Activates Replication in Saccharomyces cerevisiae
2011
PLoS ONE
The nuclear genome of eukaryotes is colonized by DNA fragments of mitochondrial origin, called NUMTs. These insertions have been associated with a variety of germ-line diseases in humans. The significance of this uptake of potentially dangerous sequences into the nuclear genome is unclear. Here we provide functional evidence that sequences of mitochondrial origin promote nuclear DNA replication in Saccharomyces cerevisiae. We show that NUMTs are rich in key autonomously replicating sequence
doi:10.1371/journal.pone.0017235
pmid:21408151
pmcid:PMC3050842
fatcat:kswujfaglbawnmiaxvfm3jvbmq