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Objective: To determine whether complement factor H (CFH Y402H) genotype influences bilateral involvement of age-related macular degeneration (AMD) lesions. . Agerelated macular degeneration retinal photographic grading used the Wisconsin system. Early and late AMD included prevalent and incident cases from all visits. CFH genotyping used TaqMan assays. Results: Of 767 AMD cases, 53.3% of early and 53.1% of late AMD cases were bilateral. After adjusting for age and other covariants, the CFH CCdoi:10.1001/archophthalmol.2009.239 pmid:19822851 fatcat:ygdolr2vcbabpawyq2mhijtqve