Case Report Primary marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type in the brain parenchyma: a case report and literature review
Int J Clin Exp Pathol
Primary central nervous system marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (MALT) type is extremely rare, and its clinical manifestations, radiological features, histopathological characteristics , and diagnosis have yet to be well elucidated. Herein, we reported a case with MZBCL of MALT type. Additionally, we reviewed the relevant literatures. A 62-year-old male presented with a 10-day history of headache and weakness in the left upper extremity. Brain magnetic
... ty. Brain magnetic resonance imaging (MRI) showed a 2.9 cm nodular lesion involving the right frontal-parietal lobe and centrum semiovale with extensive edema and remarkable enhancement. Surgical resection was performed, and gross total resection was achieved. Pathological examination revealed a MZBCL of MALT type. Immunohistochemical staining showed the lesion was positive to B-cell lymphoma 2 (Bcl-2), CD20, leukocyte common antigen (LCA), vimentin, and CD79a. The MIB-1 staining of the Ki67 antibody showed a labeling index of 30%. Genetic analysis showed immunoglobulin IGH and IGK gene and B-cell gene rearrangements. No adjuvant radiation or chemotherapy was performed. Six months after operation, brain MRI demonstrated local recurrence. Extranodal marginal zone b-cell lymphoma of mucosa-associated lymphoid tissue type occurring in the brain parenchyma is an exceedingly rare central nervous system tumor. The diagnosis depends on histopathological examinations. Surgical resection with adjuvant radiochemotherapy should be the choice of treatment.