In the last decades the development of computational approaches has undergone a major breakthrough. The growing fields of virtual screening and X-ray crystallography have a huge impact on structure-based drug design (SBDD) in developing new therapeutic agents. Drug discovery is a challenging and time-consuming process, Consequently SBDD has given a significant rule in reducing these challenges and there is a new compound is found every year, which is not introduced into the market, which

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... es that the electronic information of these possible compounds needs to be stored in a database and better understand the known chemistry. In the past decade, the role of molecular modeling in sedate plan, which has been improved, increase in computing resources and molecular models, and software development, finally introduced a competitive advantage in the first early stages of drug discovery. The process of bringing effective drugs to market requires a lot of money and time investment, in this review which shows a brief advance of SBDD in the current stages of drug discovery.