FORMATION OF THE INVERTED HEXAGONAL STRUCTURE IN BOVINE BRAIN PHOSPHOLIPID MEMBRANES INDUCED BY DIOLEOYLGLYCEROL

MUTSUO NAGANUMA, ERI HAYAKAWA, TERUO ISHIBASHI, TOMIYASU KOYAMA, TSUNEHISA ARAISO
1996 Biomedical research  
To evaluate the diacylglycerol (DG) concentration that may induce the membrane fusion, we examined the formation of the inverted hexagonal (H11) structure in the multilamellar vesicles comprised of bovine brain phosphatidylcholine (BBPC), bovine brain phosphatidylethanolamine (BBPE) and cholesterol (1 : 1: 1 molar ratio) in the absence or presence of a small amount of dioleoylglycerol (DOG). These lipid layers are considered as the model system for the secreting cell membranes. The formation of
more » ... the HM structure was detected using "P-NMR and fluorescence techniques. The fluorescent probe used was N-(dimethylaminonaphthalene-5-
doi:10.2220/biomedres.17.287 fatcat:5hd4wy75f5ctxovjyr4advylva