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Modulation of force-frequency relation by phospholamban in genetically engineered mice
1999
American Journal of Physiology. Heart and Circulatory Physiology
Modulation of force-frequency relation by phospholamban in genetically engineered mice. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H2245-H2250, 1999.-Phospholamban levels regulate cardiac sarcoplasmic reticulum Ca 2ϩ pump activity and myocardial contractility. To determine whether and to what extent phospholamban modulates the force-frequency relation and ventricular relaxation in vivo, we studied transgenic mice overexpressing phospholamban (PLBOE), gene-targeted mice without phospholamban
doi:10.1152/ajpheart.1999.276.6.h2245
fatcat:dd5fcd2drrdmzjc4shfck4qheq