Histological features of extratumoral breast lesions as a predictive factor of familial breast cancer

Mangia
2010 Oncology Reports  
The aim of this study was to verify whether histopathological features of extratumoral and of primary tumor breast tissue could play a role in identifying patients with familial characteristics. We examined the clinicopathological features of 504 patients with sporadic or familial breast cancer stratified for risk of BRCA mutation. Patients with a higher risk of being carrier of BRCA gene mutations were significantly associated with tumor poor differentiation (p=0.003), positive lymph node
more » ... ive lymph node invasion (p=0.02) and presence of vascular peritumoral invasion (p=0.008). Among the extratumoral lesions, only the epithelial proliferative lesions were related to higher mutation risk both in the overall series and familial patients (p<0.0001 and p=0.003, respectively). Interestingly, a significant difference in terms of high mutation risk was observed in usual ductal hyperplasia lesions (UDH), (p=0.002). We suggest that vascular peritumoral invasion and UDH lesions could predict a higher mutation risk of BRCA1 and BRCA2 genes and help in individuating patient candidates to further molecular analysis.
doi:10.3892/or_00000806 pmid:20428820 fatcat:gevd6ozrqfcmnaxg7jz6edl64m