Primary cns Lymphoma: Analysis of Treatment by Gamma- Knife Radiosurgery and Chemotherapy in a Prospective, Observational Study

Andres Mauricio Alvarez, Jose E Valerio, Sammie Coy
2015 Journal of Integrative Oncology  
Primary central nervous system lymphomas (PCNSL) include 4% of all primary brain-tumors. It can involve the brain parenchyma, leptomeninges, eyes and the spinal cord. Unlike systemic lymphoma, durable remissions remain uncommon. Different combinations of chemotherapy and Methotrexate are the gold standard. This is a clinical study comparing the outcomes using Methrotexate and Methrotexate with Gamma Knife Radiosurgery (GKRS). Methods: Retrospective, comparative study. Study arms, control group
more » ... rms, control group performed by Methotrexate as a single agent, in dose of 8 g/m 2 and treatment group Methrotexate and GKRS. Strict inclusion and exclusion criteria were employed and review of histologically confirmed PCNSL. Primary objective were survival rate. Secondary outcomes were the remission or re-incidence of a lesion.
doi:10.4172/2329-6771.1000150 fatcat:77sufkgaznd6tbt6ddtda7mvfi