A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf
.
A Computational Approach for Defining a Signature of β-Cell Golgi Stress in Diabetes Mellitus
2020
Diabetes
The Golgi apparatus (GA) is an important site of insulin processing and granule maturation, but whether GA organelle dysfunction and GA stress are present in the diabetic β-cell has not been tested. We utilized an informatics-based approach to develop a transcriptional signature of β-cell GA stress using existing RNA sequencing and microarray datasets generated using human islets from donors with diabetes and islets where type 1(T1D) and type 2 diabetes (T2D) had been modeled ex vivo. To narrow
doi:10.2337/db20-0636
pmid:32820009
pmcid:PMC7576569
fatcat:eovvdffifnd43bciegrw7ny7ey