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A comparative analysis of the methods used for the treatment of hemodynamic signals was carried out. Their advantages and disadvantages are noted. To eliminate one of the shortcomings, namely, the magnitude of the time lag it is suggested to use mutual information. It is known that in the theory of information, the mutual information function is used to measure the mutual dependence between two random variables.fatcat:y5qykhm2c5ckrelpi56ckrqqhi