Sport and risk of amyotrophic lateral sclerosis

Joanna Iłżecka
2019 Pedagogy and Psychology of Sport  
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor neurons. Symptoms of the disease include progressive weakness and atrophy of muscles and increasing respiratory failure. The etiology of the disease is not completely unknown. Data from the literature suggest that sport can be a risk factor for ALS through vigorous physical activity, trauma or micro trauma associated with it, and the acceptance by athletes toxic substances. Research on this topic conducted
more » ... is topic conducted in patients with ALS are not clear, but some of them point to the importance of vigorous physical activity and traumatic factors in causing 21 Iłżecka Joanna. Sport and risk of amyotrophic lateral sclerosis. Pedagogy and Psychology of Sport. 2019;9(1):21-32. elSSN 2450-6605. Original text disease. The above issues require further research. The aim of the work was a review of the literature concerning sports and risk of ALS. Keywords: amyotrophic lateral sclerosis, neurodegeneration, physical injury, sport 6. Wehrwein EA, Roskelley EM, Spitsbergen JM. GDNF is regulated in an activitydependent manner in rat skeletal muscle. Muscle Nerve. 2002; 26: 206-211. 7. Nikolaidis MG, Kyparos A, Spanou C, Paschalis V, Theodorou AA, Vrabas IS. Redox biology of exercise: an integrative and comparative consideration of some over-looked issues. J Exp Biol. 2012; 215: 1615-1625. 8. Barre's R, Yan J, Egan B, Treebak JT, Rasmussen M, Fritz T, et al. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab. 2012; 15: 405-411. 9. Dupuis L, Pradat PF, Ludolph AC, Loeffler JP. Energy metabolism in amyotrophic lateral sclerosis. Lancet Neurol. 2011; 10: 75-82.
doi:10.12775/pps.2015.05.01.004 fatcat:axcmnt2uerh7bmtqffkewjs2be