Computational Prediction of Protein–Protein Interactions

Lucy Skrabanek, Harpreet K. Saini, Gary D. Bader, Anton J. Enright
2007 Molecular Biotechnology  
Recently a number of computational approaches have been developed for the prediction of protein-protein interactions. Complete genome sequencing projects have provided the vast amount of information needed for these analyses. These methods utilize the structural, genomic and biological context of proteins and genes in complete genomes to predict protein interaction networks and functional linkages between proteins. Given that experimental techniques remain expensive, time-consuming and
more » ... ensive, these methods represent an important advance in proteomics. Some of these approaches utilize sequence data alone to predict interactions, while others combine multiple computational and experimental datasets to accurately build protein interaction maps for complete genomes. These methods represent a complementary approach to current high-throughput projects whose aim is to delineate protein interaction maps in complete genomes. In this chapter, we will describe a number of computational protocols for protein interaction prediction based on the structural, genomic and biological context of proteins in complete genomes, and detail methods for protein interaction network visualization and analysis.
doi:10.1007/s12033-007-0069-2 pmid:18095187 fatcat:6ydmlbymobeghgnqc5r3evlhuq