Negative Pressure Wound Therapy

Sven Gregor
2008 Archives of Surgery  
Objective: To systematically examine the clinical effectiveness and safety of negative pressure wound therapy (NPWT) compared with conventional wound therapy. Data Sources: MEDLINE, EMBASE, CINAHL, and the Cochrane Library were searched. Manufacturers were contacted, and trial registries were screened. Study Selection: Randomized controlled trials (RCTs) and non-RCTs comparing NPWT and conventional therapy for acute or chronic wounds were included in this review. The main outcomes of interest
more » ... comes of interest were woundhealing variables. After screening 255 full-text articles, 17 studies remained. In addition, 19 unpublished trials were found, of which 5 had been prematurely terminated. Data Extraction: Two reviewers independently extracted data and assessed methodologic quality in a standardized manner. Data Synthesis: Seven RCTs (n = 324) and 10 non-RCTs (n = 278) met the inclusion criteria. The overall methodologic quality of the trials was poor. Significant differences in favor of NPWT for time to wound closure or incidence of wound closure were shown in 2 of 5 RCTs and 2 of 4 non-RCTs. A meta-analysis of changes in wound size that included 4 RCTs and 2 non-RCTs favored NPWT (standardized mean difference: RCTs, −0.57; non-RCTs, −1.30).
doi:10.1001/archsurg.2007.54 pmid:18283145 fatcat:4e6ahbszofa3tgkdqpojlbtapy