CRISPR/Cas9-Facilitated Chromosome Engineering to Model Human Chromosomal Alterations [chapter]

Zhuo Xing, Yichen Li, Annie Pao, Garrett Kaas, Y. Eugene Yu
2018 Advances in Research on Down Syndrome  
Rodents, particularly the mouse, have been used extensively for genetic modeling and analysis of human chromosomal alterations based on the syntenic conservations between the human and rodent genomes. In this article, we will discuss the emergence of CRISPR/ Cas9-facilitated chromosome engineering techniques, which may open up a new avenue to study human diseases associated with chromosomal abnormalities, such as Down syndrome and cancer.
doi:10.5772/intechopen.70897 fatcat:hjteifcuzvc6ngsuw2y7a5d3ii