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CRISPR/Cas9-Facilitated Chromosome Engineering to Model Human Chromosomal Alterations
[chapter]
2018
Advances in Research on Down Syndrome
Preserved Fulltext
Rodents, particularly the mouse, have been used extensively for genetic modeling and analysis of human chromosomal alterations based on the syntenic conservations between the human and rodent genomes. In this article, we will discuss the emergence of CRISPR/ Cas9-facilitated chromosome engineering techniques, which may open up a new avenue to study human diseases associated with chromosomal abnormalities, such as Down syndrome and cancer.
doi:10.5772/intechopen.70897
fatcat:hjteifcuzvc6ngsuw2y7a5d3ii