To improve the patient safety among health care sector and organizations need effective and efficient leadership at all stages. Purpose: The aim of this research was to examine the impact of nurse's manager transformational leadership performance on job contentment and also towards patient safety outcomes. Methods: Random sampling of critical care nurses (N=358) was carried out through cross sectional survey in Lahore, Rawalpindi and Islamabad hospitals of Pakistan. By using structural equation

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... model technique hypothesized model was verified. Discussion: Data acceptability fit in the hypothesized model. Results highlighted that transformational leadership had solid positive impact on workstation empowerment, which resultantly enhances nurse's job satisfaction and reduces adverse patient outcomes frequency. Consequently, job satisfaction was interrelated towards lower adverse measures. Conclusion: Findings of this research provides support for manager's to adopt transformational leadership conduct as a beneficial strategy to create office environments which encourage better safety results for patients as well as nurses.