YAMA, O. E.; AMAH, C. I.; OREMOSU, A. A.; DURU, F. I. O.; OYEBADEJO, S. A.; NORONHA, C. C.; OKANLAWON, A. O. & MOJETWU, T. O. Palliative effect of Pausinystallia macroceras on testicular ischemic reperfusion injury in Wistar rats: A histological study. Int. J. Morphol., 29(4):1256-1262, 2011. SUMMARY: Testicular torsion is a disorder involving the scrotum that results in a compromise of its blood supply. The aim was to investigate the effect of Pausinystallia macroceras (PM) on testicular

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... ogy following torsion-detortion at different time intervals ranging from 1 to 4 hours 65 mature male Wister rats allotted randomly into seven groups (A to G; E& F further divided into 4subgroups). Each group/subgroup comprised 5 rats. Testis maintained in the torted position (T) for 1, 2, 3 and 4 hours in Groups A (AT1+PM), B (BT2+PM), C (CT3+PM) and D (DT4+PM). Group E subgroups (E1+PM, E2+PM, E3+PM, E4+PM -) were sham operated, without torsion served as the sham control. Group F subgroups (F1T1, F2T2, F3T3 and F4T4) were torted as in A. All animals (except groups F & G) treated with PM extract (0.1 g/kg.b.w/day) for 56 days. Group G rats (normal control). Testes processed for histological studies. In AT1+PM showed preserved seminiferous tubules. BT2+PM, revealed varying number of necrosed and apoptotic seminiferous tubules. Group CT3+PM rats were similar to BT2+PM although with a slightly higher proportion of seminiferous tubules had undergone necrosis. In DT4+PM, sections showed few viable spermatozoa within the seminiferous tubules. When compared to the torted group F; showed extensive areas of seminiferous tubular necrosis (F3T3) as well as damage to the interstitium; while in F4T4 there were no viable testicular tissues seen. In conclusion, PM significantly prevented the cellular changes and cell death observed especially in group AT1+PM and BT2+PM. KEY WORDS: Pausinystallia macroceras; Torsion-Detortion; Wister rats; Testes. IKEBUASO, A. D.; YAMA, O. E.; AMAH, C. I.; OREMOSU, A. A.; DURU, F. I. O.; OYEBADEJO, S. A.; NORONHA, C. C.; OKANLAWON, A. O. & MOJETWU, T. O. Palliative effect of Pausinystallia macroceras on testicular ischemic reperfusion injury in Wistar rats: A histological study.