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The whole-genome shotgun (WGS) assembly technique has been remarkably successful in efforts to determine the sequence of bases that make up a genome. WGS assembly begins with a large collection of short fragments that have been selected at random from a genome. The sequence of bases at each end of the fragment is determined, albeit imprecisely, resulting in a sequence of letters called a "read". Each letter in a read is assigned a quality value, which estimates the probability that a sequencingdoi:10.1089/1066527041887357 fatcat:2qdanoa5efef7ngdtmv2mduvte