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Recent advances in the treatment of the peptide design problem have led to the ability to select novel sequences given the structure of a peptide backbone. Despite these breakthroughs, issues related to the stability and functionality of these designed peptides remain sources of frustration. In this work, a novel method that addresses these issues for the computational design of peptides and proteins is introduced. The method is based on (i) in silico sequence selection for a template folddoi:10.1021/ie0340995 fatcat:pjqbqzh3urbsbntiyr3zubuozm