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BMC Medical Genetics
The human paraoxonase (PON) gene family has three isoforms: PON1, PON2 and PON3. These genes are implicated as potential risk factors of cerebrovascular disease and can prevent oxidative modification of low-density lipoproteins and atherosclerosis. This study evaluated the association between the genetic variants of all three PON genes and the risks of total stroke, ischemic stroke and hemorrhagic stroke in the Han Chinese population. Methods: A total of 1016 subjects were recruited, includingdoi:10.1186/1471-2350-14-16 pmid:23356507 pmcid:PMC3562169 fatcat:j2r4iamjzbbzfm7y4czl32iwfy