Renal stone disease (urolithiasis, nephrolithiasis) represents stone formation in kidney, ureters or bladder. The common component of urinary stone is calcium oxalate (CaOx). Gum arabic is an edible, and branches of Acacia senegal and Acacia seyal, that is rich in non-viscous soluble fiber. Male Wistar rats (150-200 g) were selected and divided into four groups. Ethylene glycol (0.75%) in drinking water was fed to all groups till 28th day to induce calculi. Group-3, 4 served as test group

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... d with Gum Arabic (250mg/kg & 500mg/kg) and group 2 standard (cystone 750 mg/kg) respectively. Blood sample collected and estimate in Serum BUN, creatinine calcium, phosphates and uric acid were also recorded. Body weight, kidney weight and urine volume were also monitored. Histological examinations of the fixed tissue sample. Statistical analysis was performed as the mean± standard deviation (SD).