Hypoxic-ischemic encephalopathy (HIE), a metabolic encephalopathy, develops as a result of cessation or reduction of oxygen and blood flow to the brain. The clinical picture may vary in severity from minimal neurologic deficits to coma. In living patients, permanent neuropsychological sequelae can develop. Herein, we present a case of HIE that occurred after anaphylactic reaction due to bee sting, which was treated with zolpidem.