Wanrui Ma,1,2 Shan He,3 Yanping Xu,4 Guoxue Qi,3 Huiyan Ma,3 John J Bang,5 P Andy Li2 1Department of General Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China; 2Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technological Enterprise (BRITE), North Carolina Central University, Durham, NC, USA; 3Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China; 4Unit of Echocardiography, Division of

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... ional Examination in Heart Center, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China; 5Department of Environmental, Earth and Geospatial Sciences, North Carolina Central University, Durham, NC, USACorrespondence: P Andy LiDepartment of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technological Enterprise (BRITE), North Carolina Central University, 1801 Fayetteville Street, Durham, NC 27707, USATel +1 919 530 6872Fax +1 919 530 6600Email pli@nccu.eduBackground: The application of silver nanoparticles (AgNPs) is growing exponentially, and its potential damage to the cardiac remains to be elucidated. The purpose of this study was to investigate the ameliorative effect of sodium selenite on silver nanoparticles-induced myocardiocyte structural alterations in rats.Materials and Methods: Forty male Sprague-Dawley (SD) rats were randomly divided into four groups: control group, AgNPs group, Se control group, and AgNPs + Se group. SD rats were administered AgNPs through a single intratracheal instillation, and sodium selenite was given by intraperitoneal injection for seven days. Cardiac function was determined by echocardiography and hemodynamic, ultrastructural changes by transmission electron microscopy examination. Mitochondrial fission and autophagy markers were measured by Western blotting.Results: AgNPs caused a significant decrease in cardiac contraction, diastolic dysfunction, fragmentation, and lysis of the myofibrils, the formation of stenosis in the capill [...]