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Tumor initiating cells in malignant gliomas: biology and implications for therapy
2009
Journal of Molecular Medicine
A rare subpopulation of cells within malignant gliomas, which shares canonical properties with neural stem cells (NSCs), may be integral to glial tumor development and perpetuation. These cells, also known as tumor initiating cells (TICs), have the ability to self-renew, develop into any cell in the overall tumor population (multipotency), and proliferate. A defining property of TICs is their ability to initiate new tumors in immunocompromised mice with high efficiency. Mounting evidence
doi:10.1007/s00109-009-0440-9
pmid:19189072
pmcid:PMC2693383
fatcat:ssbrcbcbezhv5dqucd7co6osue