Anticancer and antiproliferative properties of food-derived protein hydrolysates and peptides

Ifeanyi D. Nwachukwu, Rotimi E. Aluko
2019 Journal of food bioactives : an official scientific publication of the International Society of Nutraceuticals and Functional Foods (ISNFF)  
Cancers of all types are among the four main non-communicable diseases, a category of diseases responsible for 38 million yearly deaths worldwide. Although various medical procedures including surgery, immunotherapy, radiation therapy, hormone therapy, stem cell transplant and chemotherapy have been used for decades in the treatment and control of cancer, current survival rates suggest that more definitive and effective treatment strategies are warranted. This work provides a succinct summary
more » ... the various methods used for producing anticancer peptides and protein hydrolysates from food sources, their modes of action, as well as descriptions of their antitumour properties in cellular and animal models. Although the mechanisms by which protein hydrolysates and peptides exert their antitumor and antiproliferative effects are not entirely elucidated, there is evidence pointing to their antioxidative function as an important basis for their anticancer property.
doi:10.31665/jfb.2019.7194 fatcat:raagfbv22je6tlzmm6k3anqq4e