The research is devoted to the current issue of medicine -optimization of the treatment of cerebral strokes. It was studied the neuroprotective effect of HSP70 modulators-tamoxifen, melatonin, HSF-1 and glutamine. The research study was performed on 148 Wistar rats. An acute cerebrovascular disturbance was modeled by bilateral ligation of the common carotid arteries under thiopental anesthesia (40 mg / kg). Within 4 days, each group received treatment with one of the selected drugs (tamoxifen 1

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... mg / kg, melatonin 5 mg / kg, HSF-1 200 μl / kg, glutamine 25 mg / kg, piracetam 500 mg / kg). It was determined that on the 4 th day of the acute cerebrovascular disturbance a significant activation of oxidative stress occurs in contrast to an extreme decrease in the level of the HSP70 protein and suppression of the expression of mRNKHsp70. The studied drugs reduced the distinct features of oxidative stress (according to the nitrotyrosine marker) and increased the level of HSP70 in contrast to increase in the expression of mRNKHsp70. The results identify the ability of tamoxifen, melatonin, HSF-1 and glutamine to modulate the activity of the HSPs system, which confirms that they 76 I. F. Belenichev, Yu. V. Bila and A. M. Kamyshniy have HSP70-mediated neuroprotection mechanisms and justifies the future prospects of HSP70 regulation as an important target for neuroprotection.