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Cadmium chloride administered intraperitoneally to rats caused a mainly dose-dependent decrease of microsomal protein and the cytochrome P-450 contents in the hepatic microsomal drug-metabolizing enzyme system. This dose-dependent decrease of cytochrome b5 was slight. The concentrations of cadmium that decreased the activity of this system show no effect on sGOT and sGPT activity in this experiment. Cadmium added in vitro caused the denaturation of cytochrome P-450 to cytochrome P-420, and thedoi:10.1265/jjh.32.463 fatcat:dxbph7n3wjf4hgwlosapgr7m3e