In Vitro and In Vivo Model Systems for Studying Enteropathogenic Escherichia coli Infections

R. J. Law, L. Gur-Arie, I. Rosenshine, B. B. Finlay
2013 Cold Spring Harbor Perspectives in Medicine  
Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) belong to a group of bacteria known as attaching and effacing (A/E) pathogens that cause disease by adhering to the lumenal surfaces of their host's intestinal epithelium. EPEC and EHEC are major causes of infectious diarrhea that result in significant childhood morbidity and mortality worldwide. Recent advances in in vitro and in vivo modeling of these pathogens have contributed to our knowledge of how EPEC and EHEC
more » ... ttach to host cells and subvert hostcell signaling pathways to promote infection and cause disease. A more detailed understanding of how these pathogenic microbes infect their hosts and how the host responds to infection could ultimately lead to new therapeutic strategies to help control these significant enteric pathogens.
doi:10.1101/cshperspect.a009977 pmid:23457294 pmcid:PMC3579205 fatcat:vt2ov2vtzndwdn3dkieozvpafy