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Multi-trait association studies discover pleiotropic loci between Alzheimer's disease and cardiometabolic traits
Identification of genetic risk factors that are shared between Alzheimer's disease (AD) and other traits, i.e., pleiotropy, can help improve our understanding of the etiology of AD and potentially detect new therapeutic targets. Motivated by previous epidemiological correlations observed between cardiometabolic traits and AD, we performed a set of bivariate genome-wide association studies coupled with colocalization analysis to identify loci that are shared between AD and eleven cardiometabolicdoi:10.1101/2020.08.26.20179366 fatcat:uo4tfmls3rbvbpfo4anffaqnz4