HVJ-リポソーム法を応用した前立腺癌細胞に対する自殺遺伝子療法の検討

坪庭 直樹, 高橋 徹, 中村 吉宏, 宮川 康, 東田 章, 西村 憲二, 三浦 秀信, 辻村 晃, 松宮 清美, 奥山 明彦
2001 The Japanese Journal of Urology  
were va inated with 3T3 transfected with nee , a selecting marker , or vehicle alone , tumors were palpabLe by 13 days and lethal by 5weeks . In co コ trast, tumor growth was rctarded and survival was substantial ] y prolonged in mice vaccinated with 3T3 /PSMA or 3T3 / PSMAc 。 while PSMA − negative tumor growth was unaffected in these animals . Serum from mice va inatεd with either 3T3/ PSMA or 3T3 / PSMAc reacted with the human prostate cancer line LNCaP using immunohistochemical staining .
more » ... ical staining . 〈Conclusion>These results indicate that the 180 amino acid C − tenminal domain of PSMA may have pOtential for immunotherapy of prostate canceT . Prostate cancer lmmunotherapy PSMA
doi:10.5980/jpnjurol.92.370_1 fatcat:zqjgkitqvva7nppsiijk7ydffi