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Mucolytic bacteria license pathobionts to acquire host-derived nutrients during dietary nutrient restriction
Pathobionts employ unique metabolic adaptation mechanisms to maximize their growth in disease conditions. Adherent-invasive Escherichia coli (AIEC), a pathobiont enriched in the gut mucosa of patients with inflammatory bowel disease (IBD), utilizes diet-derived L-serine to adapt to the inflamed gut. Therefore, the restriction of dietary L-serine starves AIEC and limits its fitness advantage. Here, we find that AIEC can overcome this nutrient limitation by switching the nutrient source from thedoi:10.1101/2022.01.17.476631 fatcat:sg4zm3eudfb5telckiolr5ltoy