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Mucolytic bacteria license pathobionts to acquire host-derived nutrients during dietary nutrient restriction [article]

Kohei Sugihara, Sho Kitamoto, Prakaimuk Saraithong, Hiroko Nagao-Kitamoto, Matthew Hoostal, Alexandra Rosevelt, Chithra K Muraleedharan, Merritt G Gillilland, Jin Imai, Maiko Omi, Shrinivas Bishu, John Y Kao (+7 others)
2022 bioRxiv   pre-print

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https://web.archive.org/web/20220521053540/https://www.biorxiv.org/content/biorxiv/early/2022/01/31/2022.01.17.476631.full.pdf

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Pathobionts employ unique metabolic adaptation mechanisms to maximize their growth in disease conditions. Adherent-invasive Escherichia coli (AIEC), a pathobiont enriched in the gut mucosa of patients with inflammatory bowel disease (IBD), utilizes diet-derived L-serine to adapt to the inflamed gut. Therefore, the restriction of dietary L-serine starves AIEC and limits its fitness advantage. Here, we find that AIEC can overcome this nutrient limitation by switching the nutrient source from the
more » ... iet to the host cells in the presence of mucolytic bacteria. During diet-derived L-serine restriction, the mucolytic symbiont Akkermansia muciniphila promotes the encroachment of AIEC to the epithelial niche by degrading the mucus layer. In the epithelial niche, AIEC acquires L-serine from the colonic epithelium and thus proliferates. Our work suggests that the indirect metabolic network between pathobionts and commensal symbionts enables pathobionts to overcome nutritional restriction and thrive in the gut.
doi:10.1101/2022.01.17.476631 fatcat:sg4zm3eudfb5telckiolr5ltoy
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Kohei Sugihara, Sho Kitamoto, Prakaimuk Saraithong, Hiroko Nagao-Kitamoto, Matthew Hoostal, Alexandra Rosevelt, Chithra K Muraleedharan, Merritt G Gillilland, Jin Imai, Maiko Omi, Shrinivas Bishu, John Y Kao, Christopher Alteri, Nicolas Barnich, Thomas M. Schmidt, Asma Nusrat, Naohiro Inohara, Jonathan Louis Golob, Nobuhiko Kamada. "Mucolytic bacteria license pathobionts to acquire host-derived nutrients during dietary nutrient restriction." bioRxiv (2022)