Forsythiae Fructus Induces VEGF Production via p38 MAPK Activation in Human Keratinocytes
각질형성세포에서 p38 MAPK 활성을 통한 연교의 VEGF 생성 효과

Mi-Sun Kim, Yun Ho Choi, Sun Gyoo Park, Cheon Koo Lee, Sang Hwa Lee
2016 Journal of the Society of Cosmetic Scientists of Korea  
Cutaneous microvasculature plays a critical role in age-associated skin changes. A considerable reduction of number and size of vessels has been observed in the upper dermis of elderly skin. Forsythiae fructus (FF), the dried fruit of plant Forsythia suspensa (F. suspensa), has been traditionally used as an herbal medicine to treat inflammatory diseases and bacterial diseases. However, its regulatory effect on angiogenic responses has not been elucidated in skin. Therefore, we analyzed
more » ... profiles upon treatment of FF extract using array designed to detect angiogenesis-associated mediators in human keratinocytes. Because keratinocyte-derived VEGF (vascular endothelial growth factor) has been regarded as a potent factor for new microvasculature under the epidermis, we further investigated the effect of FF extract on VEGF production. We observed that the VEGF expression of mRNA and protein level was increased by about 2 folds in a dose-dependent manner after FF extract treatment. In signaling experiments, FF extract induced rapid p38 MAPK activation within 5 min, and the activation was totally abrogated by pretreatment with a p38 MAPK specific inhibitor. The FF-induced VEGF upregulation was also significantly attenuated by a p38 MAPK 330 김미선⋅최윤호⋅박선규⋅이천구⋅이상화 대한화장품학회지, 제 42권 제 4 호, 2016
doi:10.15230/scsk.2016.42.4.329 fatcat:lldarjk53ngrjj23hqcs5sdfgm