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Vascular risk and A interact to reduce cortical thickness in AD vulnerable brain regions
2014
Neurology
Objective: The objective of this study was to define whether vascular risk factors interact with b-amyloid (Ab) in producing changes in brain structure that could underlie the increased risk of Alzheimer disease (AD). Methods: Sixty-six cognitively normal and mildly impaired older individuals with a wide range of vascular risk factors were included in this study. The presence of Ab was assessed using [ 11 C] Pittsburgh compound B-PET imaging, and cortical thickness was measured using 3-tesla
doi:10.1212/wnl.0000000000000550
pmid:24907234
pmcid:PMC4114172
fatcat:d7w3a4vggfeypmygjpip6crmde