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Two intrathecal transplants of bone marrow mononuclear cells produce motor improvement in an acute and severe model of spinal cord injury

Elisa Lettnin Kaminski, Asdrubal Falavigna, Gianina Terribele Venturin, Daniel Marinowic, Pamela Brambilla Bagatini, Léder Leal Xavier, Jaderson Costa DaCosta
2013 Coluna/Columna  

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OBJECTIVE: We studied transplants of bone marrow mononuclear cells (BMMC) by lumbar puncture (LP) in a severe model of spinal cord injury (SCI) using clip compression. METHODS: BMMCs or saline solution were transplanted by LP 48 hours and 9 days post injury. Motor function was evaluated by BBB scale, histological analysis by Nissl technique and the verification of cell migration by PCR analysis. RESULTS: The BBB had significantly improved in rats treated with BMMCs by LP compared with controls
more » ... p<0.001). The histological analysis did not showed difference in the lesional area between the groups. The PCR analysis was able to found BMMCs in the injury site. CONCLUSIONS: two BMMC transplants by LP improved motor function in a severe model of SCI and BMMC was found in the injury site.
doi:10.1590/s1808-18512013000400001 fatcat:ly2sed5iybhoxoup7z6itkibjy
DOAJ SciELO
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Elisa Lettnin Kaminski, Asdrubal Falavigna, Gianina Terribele Venturin, Daniel Marinowic, Pamela Brambilla Bagatini, Léder Leal Xavier, Jaderson Costa DaCosta. "Two intrathecal transplants of bone marrow mononuclear cells produce motor improvement in an acute and severe model of spinal cord injury." Coluna/Columna 12.4 (2013) 274-277