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Activation of Protein Kinase D by Signaling through Rho and the α Subunit of the Heterotrimeric G Protein G13
2001
Journal of Biological Chemistry
Protein kinase D (PKD/PKC) immunoprecipitated from COS-7 cells transiently transfected with either a constitutively active mutant of Rho (RhoQ63L) or the Rho-specific guanine nucleotide exchange factor pOnco-Lbc (Lbc) exhibited a marked increase in basal activity. Addition of aluminum fluoride to cells co-transfected with PKD and wild type G␣ 13 also induced PKD activation. Co-transfection of Clostridium botulinum C3 toxin blocked activation of PKD by RhoQ63L, Lbc, or aluminum
doi:10.1074/jbc.m105530200
pmid:11507098
fatcat:k2bubgxxqnd3tkgvr3cw5z75wq